Proton pump inhibitors substantially raise the risk of hospital-related C. difficile infection and clinicians “should strongly consider restricting” their use, US researchers say.
Hospital patients were almost twice as likely to contract a C. difficile infection (CDI) if they had received a PPI, the study of 200 CDI patients and matched controls showed.
There was a dose response, with the likelihood of a CDI increasing with longer durations of PPI therapy, the authors from the Midwestern University College of Pharmacy found.
Other factors significantly associated with CDI were prior hospitalisation within 30 days,
Hospital patients were almost twice as likely to contract a C. difficile infection (CDI) if they had received a PPI, the study of 200 CDI patients and matched controls showed.
There was a dose response, with the likelihood of a CDI increasing with longer durations of PPI therapy, the authors from the Midwestern University College of Pharmacy found.
Other factors significantly associated with CDI were prior hospitalisation within 30 days,
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